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Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP


Clinical History:
Post menopausal breast cancer patient receiving Tamoxifen therapy, routine examination


Cytomorphologic Criteria:
Loose aggregates of "naked" nuclei. Nuclear molding is seen, without cytoplasm.

Explanatory Notes:
Naked nuclei should not to be mistaken for endometrial cells. They are seen in a variety of conditions (atrophy, hormone therapy, antiestrogen therapy.) They are most likely naked squamous cell nuclei. In women taking hormone therapy or nonsteroidal antiestrogen compounds, these cells "stand out" against the background keratinized epithelial cells.

Asymptomatic after 3 years

See Also: thumbnail for figure EMS_naked_nuclei_TP_low.jpg
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