Type of Preparation: ThinPrep/ LBP Magnification: Medium Clinical History: 54 year old receiving hormone replacement therapy Interpretation: NILM Cytomorphologic Criteria: Loose aggregates of naked nuclei. There is nuclear molding and absent cytoplasm. Explanatory Notes: Small naked nuclei may be seen in a variety of conditions, including atrophy, hormone therapy and Tamoxifen therapy. They are most likely naked squamous cell nuclei. In women taking hormone therapy or nonsteroidal antiestrogen compounds, these cells "stand out" against the background keratinized epithelial cells. They should not be reported as endometrial cells. Follow-up: No symptoms of endometrial abnormality and negative follow up for 3 years