Type of Preparation: ThinPrep/ LBP Magnification: High Clinical History: 47 year old female; no LMP available Interpretation: Endometrial cells are present in a woman >= 40 years of age. Negative for squamous intraepithelial lesion. (See Note) Note: Endometrial cells after age 40, particularly out of phase or after menopause may be associated with benign endometrium, hormonal alterations and less commonly, endometrial /uterine abnormalities. Clinical correlation is recommended. Cytomorphologic Criteria: Tight, three dimensional group. No stroma seen. Nuclei are similar in size, but irregular. Vacuole in cytoplasm at lower right. Otherwise, scant cytoplasm. Explanatory Notes: Endometrial cells are reported in women at age 40 or older due to the rare occurrence of endometrial carcinoma accompanied only by benign appearing endometrial cells. The nuclear features of endometrial cells on ThinPrep may be disturbing. Nuclear irregularity and accentuated chromatin patterns are seen on ThinPrep slides. The nuclei are not as well preserved and as easily seen on conventional smears. Follow-up: No evidence of endometrial pathology 2 years later. Subsequent Pap tests were negative