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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
50 year old female with no menstrual history available

Interpretation:
Endometrial cells are present in a woman >= 40 years of age. Negative for squamous intraepithelial lesion. (See Note)
Note: Endometrial cells after age 40, particularly out of phase or after menopause may be associated with benign endometrium, hormonal alterations and less commonly, endometrial /uterine abnormalities. Clinical correlation is recommended.

Cytomorphologic Criteria:
Exodus pattern is characterized by a double contour pattern of external glandular epithelium with internal stromal cells. The stroma in this group is slightly eccentric. Nuclear features are easily appreciated, despite this being a conventional Pap smear. The nuclei have delicate even chromatin. Histiocytes are often seen in association with the double contour fragments of exodus.

Explanatory Notes:
Exfoliated glandular endometrium may be seen when evaluating Pap tests. When endometrial cells are encountered in a woman 40 or older, they are uncommonly associated with significant pathology. Rarely, cytologically "typical or benign appearing" endometrial cells may be associated with an asymptomatic endometrial carcinoma in this age group. Because of this association, all glandular endometrial cells are reported in women 40 years and over.


See Also: thumbnail for figure EMS_exodus_TP002.jpg
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