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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
61 year old female with postmenopausal bleeding

Interpretation:
Adenocarcinoma, Endometrial

Cytomorphologic Criteria:
Loose aggregate of small epithelial cells with slightly enlarged nuclei, small nucleoli, and vacuolated cytoplasm; "watery diathesis" and histiocytes also noted.

Explanatory Notes:
In conventional smears, endometrial adenocarcinoma is more commonly associated with a thin watery diathesis in the smear background in contrast to the bloody, necrotic background associated with endocervical adenocarcinoma.

Follow-up:
Endometrial adenocarcinoma, Grade 1.

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 2 0%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 5 1%
ASC-US # people picked ASC-US 3 1%
ASC-H # people picked ASC-H 21 4%
LSIL # people picked LSIL 1 0%
HSIL # people picked HSIL 119 22%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 21 4%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 19 3%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 91 16%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 13 2%
Adenocarcinoma # people picked Adenocarcinoma 258 47%
 
553 interpretations were submitted.

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