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Atlas Interpretation:
Interpreted image
Type of Preparation:


Clinical History:
64 year old woman with history of an abnormal Pap test at another institution referred for workup

Endocervical adenocarcinoma in situ (AIS)

Cytomorphologic Criteria:
Aggregate of abnormal cells with elongated hyperchromatic nuclei arranged in glandular strips that have nuclear pseudostratification and suggestion of a gland lumen. There is some suggestion of feathering at the periphery.

Explanatory Notes:
Cells with elongated nuclei and nuclear pseudostratification are classic features of endocervical AIS. Feathering at the periphery of cells sheets may be more subtle in liquid-based preparations.

endocervical adenocarcinoma in situ with a small component of invasive adenocarcinoma and a co-existing HSIL

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 10 2%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 3 1%
ASC-US # people picked ASC-US 3 1%
ASC-H # people picked ASC-H 12 2%
LSIL # people picked LSIL 2 0%
HSIL # people picked HSIL 23 4%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 5 1%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 87 15%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 11 2%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 384 67%
Adenocarcinoma # people picked Adenocarcinoma 37 6%
577 interpretations were submitted.

See Also: thumbnail for figure DS-51.jpg
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