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Atlas Interpretation:
Type of Preparation:
ThinPrep
Magnification:
Medium
Clinical History:
64 year old woman with history of an abnormal Pap test at another institution referred for workup
Interpretation:
Endocervical adenocarcinoma in situ (AIS)
Cytomorphologic Criteria:
Aggregate of abnormal cells with elongated hyperchromatic nuclei arranged in glandular strips that have nuclear pseudostratification and suggestion of a gland lumen. There is some suggestion of feathering at the periphery.
Explanatory Notes:
Cells with elongated nuclei and nuclear pseudostratification are classic features of endocervical AIS. Feathering at the periphery of cells sheets may be more subtle in liquid-based preparations.
Follow-up:
endocervical adenocarcinoma in situ with a small component of invasive adenocarcinoma and a co-existing HSIL
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Bethesda Interobserver Reproducibility Data:
See Also:
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