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Atlas Interpretation:
Interpreted image
Type of Preparation:


Atypical endocervical cells, NOS, HSIL

Cytomorphologic Criteria:
Cluster of cells showing crowding and overlapping of nuclei, nuclear enlargement, chromocenters, and small nucleoli.

Explanatory Notes:
HSIL involving gland spaces may present as contoured clusters that mimic the appearance of glandular lesions. Note the absence of elongated nuclei, feathering, rosettes, and pseudostratified strips, features that are typically associated with endocervical AIS.

High grade squamous intraepithelial lesion only

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 30 5%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 9 2%
ASC-US # people picked ASC-US 0 0%
ASC-H # people picked ASC-H 3 1%
LSIL # people picked LSIL 0 0%
HSIL # people picked HSIL 17 3%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 7 1%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 100 17%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 139 24%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 121 21%
Adenocarcinoma # people picked Adenocarcinoma 147 26%
573 interpretations were submitted.

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