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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
39 year old woman, routine Pap smear, no LMP date given

Interpretation:
Atypical endocervical cells, NOS

Cytomorphologic Criteria:
Sheet of cells with enlarged round or oval nuclei with prominent nucleoli. Chromatin is finely granular and evenly distributed but occasional chromocenters are seen. Cell borders are well-defined. Mitotic figures are noted.

Explanatory Notes:
In some cases, atypical glandular cells associated with benign processes may be difficult to differentiate from neoplastic processes, especially when mitotic activity is prominent.

Follow-up:
ECC and multiple follow-up Pap smears over three years were negative and the patient have no other gynecologic findings. In view of the benign follow-up, the cytologic atypia and mitotic activity are thought to represent endocervical repair

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 125 20%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 3 0%
ASC-US # people picked ASC-US 22 4%
ASC-H # people picked ASC-H 18 3%
LSIL # people picked LSIL 4 1%
HSIL # people picked HSIL 54 9%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 35 6%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 172 28%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 16 3%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 61 10%
Adenocarcinoma # people picked Adenocarcinoma 105 17%
 
615 interpretations were submitted.

See Also: thumbnail for figure AGCCAEC-J01.jpg
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