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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
34 year old woman on oral contraceptives, Day 19

Interpretation:
NILM: Microglandular hyperplasia

Cytomorphologic Criteria:
These are degenerating endocervical cells in a streaming pattern that has been associated with microglandular hyperplasia. It is typically seen in second half of the menstrual cycle in women taking oral contraceptives and may mimic HSIL at low magnification.

Explanatory Notes:
Degenerating endocervical cells can appear to be "pseudoparakeratotic" and this cytoplasmic feature should not be misinterpreted as favoring squamous origin.

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 279 60%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 59 13%
ASC-H # people picked ASC-H 67 14%
LSIL # people picked LSIL 12 3%
HSIL # people picked HSIL 41 9%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 5 1%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 0 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 0 0%
Adenocarcinoma # people picked Adenocarcinoma 0 0%
 
463 interpretations were submitted.

See Also: thumbnail for figure DS-518.jpg
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