NCI Bethesda System 2001 logo American Society of Cytopathology logo
 Main Page 
 Search By:
   Atlas Chapter 
   Atlas Figure # 
   Terminology Table 
   Preparation Type 
   BIRP Images 

[Back to Listing]
Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP


Clinical History:
42 year old woman

HSIL, r/o invasion

Cytomorphologic Criteria:
Keratinized dysplastic cells with nucleoli, and angulated or ?carrot? shaped nuclei that may raise suspicion for invasion and qualify for an interpretation of HSIL, cannot rule out invasion.

Explanatory Notes:
Cells consistent with CIS are generally round to oval and of similar size. When the lesion is "keratinizing" it is often more difficult to classify the degree of abnormality present with certainty.

Biopsy- CIN 3 (severe dysplasia, keratinizing)

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 3 1%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 49 10%
ASC-H # people picked ASC-H 23 5%
LSIL # people picked LSIL 165 33%
HSIL # people picked HSIL 125 25%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 142 28%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 0 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 0 0%
Adenocarcinoma # people picked Adenocarcinoma 0 0%
507 interpretations were submitted.

See Also: thumbnail for figure JC-SCCA.jpg
[Back to Listing]
Definitions of terms used in this site