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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
28 year old woman, LMP 3 weeks, routine exam

Interpretation:
LSIL/HSIL (Borderline)

Cytomorphologic Criteria:
Borderline LSIL/ HSIL. The abnormal cells characterizing moderate dysplasia have a fair amount of cytoplasm compared to severe dysplasia/ CIN3, but less than that in LSIL cells. These cells are at the borderline of what may be interpreted as LSIL by some and HSIL by others.

Explanatory Notes:
While the majority of SIL cases can be classified as HSIL or LSIL, in occasional cases, the distinction between LSIL and HSIL may not be possible. However note that mildly dysplastic cells are often seen in slide preparations diagnostic of more severe lesions. Histologic follow-up of such cases is LSIL or if HSIL, it tends to be CIN 2 (moderate dysplasia).

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 35 7%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 119 23%
ASC-H # people picked ASC-H 97 19%
LSIL # people picked LSIL 158 31%
HSIL # people picked HSIL 98 19%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 0 0%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 0 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 0 0%
Adenocarcinoma # people picked Adenocarcinoma 0 0%
 
507 interpretations were submitted.

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