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Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP


Clinical History:
31 year old


Cytomorphologic Criteria:
A cluster of HSIL cells. Important features of high grade squamous intraepithelial lesions are enlarged, centrally placed nuclei, hyperchromasia, and irregular nuclear membranes.

Explanatory Notes:
The presence of koilocytes in other cells on the smear supports an interpretation of squamous intraepithelial lesion. In this case HSIL is present, and the highest grade of abnormality present in the smear is what should be reported.

Biopsy- CIN 3

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 0 0%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 1 0%
ASC-H # people picked ASC-H 9 2%
LSIL # people picked LSIL 0 0%
HSIL # people picked HSIL 448 88%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 41 8%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 4 1%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 2 0%
Adenocarcinoma # people picked Adenocarcinoma 7 1%
512 interpretations were submitted.

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