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Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP


Clinical History:
29 year old, from "high-risk" clinic


Cytomorphologic Criteria:
In liquid-based preparations, cells from HSIL are often isolated, small in size and have nuclei that are slightly larger than an intermediate cell nucleus. Dense cytoplasm and centrally placed nuclei are consistent with a squamous origin.

Explanatory Notes:
Close attention to isolated cells is required when screening liquid based preparations since the abnormal cells tend to be isolated and may not be as apparent as clusters of HSIL cells. Additionally, these isolated cells may lie between benign cell clusters or in ?empty spaces? on the preparation. When the criteria for HSIL are met, such cells should be interpreted as HSIL and not ASC-H.

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 4 1%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 7 1%
ASC-H # people picked ASC-H 121 23%
LSIL # people picked LSIL 2 0%
HSIL # people picked HSIL 374 72%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 2 0%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 3 1%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 5 1%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 1 0%
Adenocarcinoma # people picked Adenocarcinoma 2 0%
521 interpretations were submitted.

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