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Atlas Interpretation:
Type of Preparation:
ThinPrep/ LBP
Magnification:
High
Clinical History:
29 year old, from "high-risk" clinic
Interpretation:
HSIL
Cytomorphologic Criteria:
In liquid-based preparations, cells from HSIL are often isolated, small in size and have nuclei that are slightly larger than an intermediate cell nucleus. Dense cytoplasm and centrally placed nuclei are consistent with a squamous origin.
Explanatory Notes:
Close attention to isolated cells is required when screening liquid based preparations since the abnormal cells tend to be isolated and may not be as apparent as clusters of HSIL cells. Additionally, these isolated cells may lie between benign cell clusters or in ?empty spaces? on the preparation. When the criteria for HSIL are met, such cells should be interpreted as HSIL and not ASC-H.
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Bethesda Interobserver Reproducibility Data:
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