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Atlas Interpretation:
Type of Preparation:
Conventional
Magnification:
High
Clinical History:
42 year old woman, LMP 2 weeks
Interpretation:
HSIL
Cytomorphologic Criteria:
This large cluster of cells exhibits a loss of polarity, nuclear enlargement and coarsely granular chromatin. Together with a high nuclear to cytoplasmic ratio, a diagnosis of HSIL is warranted. Some nuclei display discrete nucleoli.
Explanatory Notes:
Although uncommon, nucleoli may be seen in HSIL, especially with extension into endocervical gland spaces. The chromatin may also appear less coarsely granular in these cases. Thus the presence of nucleoli in dysplastic squamous cells in itself is not a specific morphologic indicator of "invasion" in a squamous epithelial abnormality.
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Bethesda Interobserver Reproducibility Data:
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