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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Interpretation:
HSIL

Cytomorphologic Criteria:
Loose aggregate of HSIL cells with some variation in cell size and N/C ratios, irregular nuclear membranes and granular chromatin. Note that some of the metaplastic cells still show mucin/ endocervical features.

Explanatory Notes:
Single dysplastic cells in a streaming pattern, especially at low power may mimic histiocytes A cluster such as this may raise the differential diagnosis of squamous metaplastic cells under lower magnification. Attention to nuclear details is essential to make these distinctions.

Follow-up:
Biopsy was CIN 3 (carcinoma in situ/ sever dysplasia)

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 68 11%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 14 2%
ASC-US # people picked ASC-US 17 3%
ASC-H # people picked ASC-H 108 17%
LSIL # people picked LSIL 3 0%
HSIL # people picked HSIL 324 52%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 2 0%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 42 7%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 22 4%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 8 1%
Adenocarcinoma # people picked Adenocarcinoma 12 2%
 
620 interpretations were submitted.

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