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Atlas Interpretation:
Type of Preparation:
ThinPrep/ LBP
Magnification:
High
Clinical History:
32 year old with prior abnormal Pap test
Interpretation:
ASC-US vs LSIL
Cytomorphologic Criteria:
Clusters of abnormal squamous cells may be seen in ?spike-like? aggregates. These clusters should be classified as NILM, ASC, or SIL based on the degree of nuclear abnormalities. This patient had an LSIL interpretation on a conventional smear, two months prior to this LBP, that was interpreted as ASC-US (atypical PK).
Explanatory Notes:
Limited personal experiences suggest that this pattern is more frequent in liquid based preparations. It has been hypothesized that it may represent the Pap Test equivalent of a histologic "condylomatous spike". Limited correlation with HPV testing suggests that cases showing this pattern (and without obvious SIL elsewhere in the Pap test) can be positive for high-risk HPV.
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Bethesda Interobserver Reproducibility Data:
See Also:
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