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Atlas Interpretation:
Interpreted image
Type of Preparation:
SurePath/ LBP


Clinical History:
22 year old


Cytomorphologic Criteria:
Mature squamous cells displaying enlarged nuclei with a granular chromatin distribution meet the criteria for interpretation as LSIL. Binucleation and koilocytosis are consistent with HPV cytopathic effect.

Explanatory Notes:
Nuclei are 3 to 4 times the size of normal intermediate cell nuclei. Nuclear hyperchromasia may not be as obvious in LBP?s as compared to conventional smears, however other criteria for interpretation of SIL are present.

Follow-up: CIN 1

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 8 2%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 39 7%
ASC-H # people picked ASC-H 0 0%
LSIL # people picked LSIL 473 90%
HSIL # people picked HSIL 7 1%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 0 0%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 1 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 0 0%
Adenocarcinoma # people picked Adenocarcinoma 0 0%
528 interpretations were submitted.

See Also: thumbnail for figure TBS-LSIL-DD6.jpg
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