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Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP

Magnification:
High

Clinical History:
32 year old, LMP: 20 days, routine screening

Interpretation:
LSIL

Cytomorphologic Criteria:
HPV nuclear and cytoplasmic changes (binucleation and koilocytosis) are consistent with LSIL. Note that in addition to perinuclear cavitation, nuclear abnormalities as seen here are required to make an interpretation of LSIL.

Explanatory Notes:
Nuclear size is only 2 times larger than intermediate nuclei, but chromatin pattern is granular and nuclear membranes are irregular.

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 5 1%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 10 2%
ASC-H # people picked ASC-H 3 0%
LSIL # people picked LSIL 607 97%
HSIL # people picked HSIL 3 0%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 0 0%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 0 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 0 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 1 0%
Adenocarcinoma # people picked Adenocarcinoma 0 0%
 
629 interpretations were submitted.

See Also: thumbnail for figure DW75.jpg
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