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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
75 year old woman with post menopausal bleeding. Patient has no prior history of malignancy

Interpretation:
Other Malignant Neoplasms: Malignant lymphoma, large cell type

Cytomorphologic Criteria:
These single cells in a bloody background have enlarged hyperchromatic nuclei and irregular nuclear membranes. Chromatin is coarse, and irregularly distributed with prominent nucleoli.

Explanatory Notes:
Involvement of the cervix by malignant lymphoma is rare, and secondary involvement is more common than primary tumors. A large number of atypical lymphoid cells should elicit the diagnosis. The main differential diagnosis is follicular cervicitis.

Follow-up:
Large cell lymphoma confirmed by cervical biopsy. Additional workup confirmed a diagnosis of lymphoma in other sites


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