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Atlas Interpretation:
Type of Preparation: Conventional
Magnification: High
Clinical History: 75 year old woman with post menopausal bleeding. Patient has no prior history of malignancy
Interpretation:
Other Malignant Neoplasms: Malignant lymphoma, large cell type
Cytomorphologic Criteria: These single cells in a bloody background have enlarged hyperchromatic nuclei and irregular nuclear membranes. Chromatin is coarse, and irregularly distributed with prominent nucleoli.
Explanatory Notes: Involvement of the cervix by malignant lymphoma is rare, and secondary involvement is more common than primary tumors. A large number of atypical lymphoid cells should elicit the diagnosis. The main differential diagnosis is follicular cervicitis.
Follow-up: Large cell lymphoma confirmed by cervical biopsy. Additional workup confirmed a diagnosis of lymphoma in other sites
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