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Atlas Interpretation:
Interpreted image
Type of Preparation:
ThinPrep/ LBP

Magnification:
Medium

Clinical History:
69 year old postmenopausal female. S/P TAH/BSO for Stage 2 endometrial adenocarcinoma. H/O VAIN 10 years ago. Vaginal ThinPrep

Interpretation:
ASC-H

Cytomorphologic Criteria:
Atypical multinucleated cell.

Explanatory Notes:
Atypical cells may be seen in atrophy, but the differential includes a high grade lesion. Repeat sampling following a course of estrogen may clarify the findings.

Follow-up:
Vaginal cuff biopsies and repeat Pap test 2 months later showed severe dysplasia/CIS (CIN 3)

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 1 0%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 0 0%
ASC-US # people picked ASC-US 30 6%
ASC-H # people picked ASC-H 83 16%
LSIL # people picked LSIL 91 18%
HSIL # people picked HSIL 271 54%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 11 2%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 1 0%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 2 0%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 1 0%
Adenocarcinoma # people picked Adenocarcinoma 13 3%
 
504 interpretations were submitted.

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