Type of Preparation: Conventional Magnification: High Clinical History: 32 year old woman with soft polypoid lesion of the cervix Interpretation: Other Malignant Neoplasms: Spindle Cell Carcinoma Cytomorphologic Criteria: This loosely cohesive group of spindled non-keratinizing cells display variability in nuclear size, nuclear membrane irregularity, coarse granular chromatin and conspicuous nucleoli. The cytologic features are compatible with a malignant spindle cell neoplasm. Explanatory Notes: In the absence of keratinized cells, the cytologic features of this spindle cell neoplasm are not specific. The findings may be compatible with spindle cell sarcoma or malignant melanoma. If liquid based cytology is used, performing immunostains (keratin and S-100 protein) may help classify the tumor. Follow-up: Spindle cell carcinoma (hysterectomy)