Type of Preparation: Conventional Magnification: High Clinical History: 40 year old woman s/p resection of melanoma of the thigh presents with a small discolored submucosal lesion on the cervix; LMP 4 weeks Interpretation: Other Malignant Neoplasms: Malignant melanoma Cytomorphologic Criteria: Large single or loosely cohesive cells with round nuclei, irregular nuclear membranes, coarsely clumped irregularly distributed chromatin and prominent nucleoli are compatible with a poorly differentiated neoplasm. Explanatory Notes: The presence of intranuclear pseudoinclusion and melanin pigment is helpful in arriving at a definitive diagnosis. Additionally if material from LBP sample is available, immunostains for S-100 protein, HMB-45 and Melanin-A may help confirm the diagnosis. Malignant melanoma in the cervix may arise as a primary tumor but is most frequently encountered as a metastasis in patients with known primaries. Follow-up: Cells in Pap smear are identical to those seen in her previous tissue interpreted as malignant melanoma