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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
64 year old postmenopausal woman with extensive Paget disease of vulva that appears to extend into the vagina

Interpretation:
Other Malignant Neoplasms: Paget disease

Cytomorphologic Criteria:
The vaginal smear has loosely cohesive groups and single cells with pleomorphic hyperchromatic nuclei, irregular clumped chromatin, prominent nucleoli, and moderate amounts of cytoplasm. A cytoplasmic vacuole within the binucleated cell is suggestive of glandular differentiation.

Explanatory Notes:
The cytologic features, although diagnostic of malignancy and consistent with adenocarcinoma, are not specific for Paget disease. History and comparison with primary tumor support that interpretation.

Follow-up:
Compared with prior tissue


See Also: thumbnail for figure Misc-tiss-st2.jpg
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