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Atlas Interpretation:
Interpreted image
Type of Preparation:


Clinical History:
64 year old postmenopausal woman with extensive Paget disease of vulva that appears to extend into the vagina

Other Malignant Neoplasms: Paget disease

Cytomorphologic Criteria:
The vaginal smear has loosely cohesive groups and single cells with pleomorphic hyperchromatic nuclei, irregular clumped chromatin, prominent nucleoli, and moderate amounts of cytoplasm. A cytoplasmic vacuole within the binucleated cell is suggestive of glandular differentiation.

Explanatory Notes:
The cytologic features, although diagnostic of malignancy and consistent with adenocarcinoma, are not specific for Paget disease. History and comparison with primary tumor support that interpretation.

Compared with prior tissue

See Also: thumbnail for figure Misc-tiss-st2.jpg
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