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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
85 year old postmenopausal woman 2 years s/p partial colectomy for colon cancer now presents with ulcerative lesion on the cervix and a large pelvic mass

Interpretation:
Other Malignant Neoplasms: Adenoid cystic carcinoma

Cytomorphologic Criteria:
Thick groups of cells arranged in distinctive spherules/cysts surrounding glassy/hyaline stromal/basement membrane globules. The cells are basaloid with small slightly pleomorphic nuclei, and high nuclear to cytoplasmic ratio. Increased mitoses may be present.

Explanatory Notes:
Adenoid cystic carcinoma of the cervix usually occurs in postmenopausal woman. The appearance of adenoid cystic carcinoma in cervical material is similar to that encountered in salivary glands and other body sites. In the cervix, adenoid cystic carcinoma may be associated with other cervical primaries. The differential diagnosis includes adenoid basal carcinoma, a tumor which is not well described cytologically, that is composed of similar basaloid cells without the stromal hyaline globules.

Follow-up:
Cervix biopsy showed adenoid cystic carcinoma and squamous carcinoma in -situ. This lesion did not resemble the patient's colon cancer


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