NCI Bethesda System 2001 logo American Society of Cytopathology logo
 Main Page 
 Search By:
   Atlas Chapter 
   Atlas Figure # 
   Terminology Table 
   Keyword 
   Preparation Type 
   BIRP Images 
 Self-Test 
 Acknowledgments 
 Links 
 Feedback 

[Back to Listing]
Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
71 year old postmenopausal woman

Interpretation:
HSIL with some features suspicious for invasion

Cytomorphologic Criteria:
Small squamous cells with irregular hyperchromatic nuclei and high N/C ratios. There is some necrotic cellular debris in the background, which raises the question of possible invasion.

Explanatory Notes:
HSIL involving endocervical glands may undergo central necrosis when those glands become occluded. In conventional smears, necrotic cellular debris may be seen as focal aggregates of debris (usually associated with abnormal epithelial cells) in an otherwise clean background. This differs from the necrotic debris admixed with broken down blood and inflammation that usually seen in diathesis with invasive lesions. This is an unusual and difficult pattern on Pap tests.

Follow-up:
HSIL extending into glands with focal epithelial cell necrosis within occluded glands but no invasion


See Also: thumbnail for figure DW65.jpg
[Back to Listing]
Definitions of terms used in this site