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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
58 year old postmenopausal woman on HRT

Interpretation:
HSIL

Cytomorphologic Criteria:
Hyperchromatic crowded groups seen at low power require careful examination at higher magnification. Under close scrutiny, this hyperchromatic crowded group show at the edge loosely cohesive cells that are morphologically consistent with HSIL.

Explanatory Notes:
Nuclear overlap, hyperchromasia and dense cytoplasm are consistent with a squamous origin. Note the "flattening" of cells at the periphery of the group on the upper right side of the cluster. Flattening at the edge of the cell cluster and whorling in the center are suggestive of HSIL over a glandular epithelial abnormality. Careful appraisal of the remaining smear for overall cell pattern and single dysplastic cells is also extremely important.


See Also: thumbnail for figure DW99.jpg
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