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Atlas Interpretation:
Interpreted image
Type of Preparation:
SurePath/ LBP


Clinical History:
35 year old


Cytomorphologic Criteria:
On low magnification, this large "hyperchromatic" cluster of cells displays enlarged nuclei and a high nuclear to cytoplasmic ratio. The dense cytoplasm suggests a squamous origin. The pattern is consistent with CIS.

Explanatory Notes:
As in conventional smears, crowded hyperchromatic cell groups should be examined with care. If a squamous abnormality is suspected, a thorough search for single dysplastic cells in the background is warranted. SIL occasionally presents morphologically as spindle cells.

Biopsy-CIN 3 (severe dysplasia/carcinoma in situ)

See Also: thumbnail for figure JC-HSIL10.jpg
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