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Atlas Interpretation:
Interpreted image
Type of Preparation:
SurePath/ LBP


Clinical History:
44 year old woman


Cytomorphologic Criteria:
Such ?hyperchromatic crowed groups? may raise a wide differential diagnosis under low magnification; attention to architectural pattern and cellular detail are necessary for correct interpretation. In this image, the enlarged nuclei with hyperchromatic/granular chromatin, dense cytoplasm and high N/C ratio cells arranged in a syncytial cluster such as this warrant an interpretation of HSIL/CIS.

Explanatory Notes:
The nuclei in this tightly arranged group are too large to be endometrial cells. Other differential diagnosis of such "hyperchromatic clusters" include atrophy/ parabasal cells, lower uterine segment, glandular epithelial abnormalities and HSIL extension into endocervical gland spaces.

Biopsy- CIN 3 (severe dysplasia/CIS)

See Also: thumbnail for figure DS-41.jpg
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