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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
High

Clinical History:
42 year old woman with history of breast cancer.

Interpretation:
Adenocarcinoma, extrauterine (Breast carcinoma)

Cytomorphologic Criteria:
Group of dissociated cells with malignant features including high nuclear to cytoplasmic ratio, hyperchromatic, slightly irregular nuclei and conspicuous nucleoli. A finely vacuolated cytoplasm is consistent with glandular differentiation.

Explanatory Notes:
Presence of signet ring cells and cell-in-cell arrangement may suggest breast carcinoma. Typically the cervical preparation would lack tumor diathesis in metastatic tumors. The differential diagnosis includes metastatic gastric carcinoma as well as other adenocarcinomas, NOS.

Follow-up:
Metastatic breast cancer


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