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Atlas Interpretation:
Interpreted image
Type of Preparation:
SurePath/ LBP

Magnification:
High

Clinical History:
Routine Pap test

Interpretation:
NILM: Cellular changes consistent with Herpes simplex virus

Cytomorphologic Criteria:
The multinucleated squamous epithelial cell (top) shows degeneration of nuclei, whereas the multinucleated squamous cell (below center) shows the typical molded nuclei of HSV infection (pomegranate seed appearance). Faint nuclear inclusions are evident in this cell and a uninucleate cell beneath.

Explanatory Notes:
Nuclei have "ground glass" effect due to intranuclear viral particles and enhancement of the nuclear envelope caused by peripheral margination of the chromatin. Multinucleated cells are not always present.


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