NCI Bethesda System 2001 logo American Society of Cytopathology logo
 Main Page 
 Search By:
   Atlas Chapter 
   Atlas Figure # 
   Terminology Table 
   Preparation Type 
   BIRP Images 

[Back to Listing]
Atlas Interpretation:
Interpreted image
Type of Preparation:
SurePath/ LBP


Clinical History:
Routine Pap test

NILM: Cellular changes consistent with Herpes simplex virus

Cytomorphologic Criteria:
The multinucleated squamous epithelial cell (top) shows degeneration of nuclei, whereas the multinucleated squamous cell (below center) shows the typical molded nuclei of HSV infection (pomegranate seed appearance). Faint nuclear inclusions are evident in this cell and a uninucleate cell beneath.

Explanatory Notes:
Nuclei have "ground glass" effect due to intranuclear viral particles and enhancement of the nuclear envelope caused by peripheral margination of the chromatin. Multinucleated cells are not always present.

[Back to Listing]
Definitions of terms used in this site