Type of Preparation: SurePath/ LBP Magnification: High Clinical History: Routine Pap test Interpretation: NILM: Cellular changes consistent with Herpes simplex virus Cytomorphologic Criteria: The multinucleated squamous epithelial cell (top) shows degeneration of nuclei, whereas the multinucleated squamous cell (below center) shows the typical molded nuclei of HSV infection (pomegranate seed appearance). Faint nuclear inclusions are evident in this cell and a uninucleate cell beneath. Explanatory Notes: Nuclei have "ground glass" effect due to intranuclear viral particles and enhancement of the nuclear envelope caused by peripheral margination of the chromatin. Multinucleated cells are not always present.