Type of Preparation: ThinPrep Magnification: Medium Clinical History: 39 year old woman s/p resection of colon carcinoma presents with lesion in left fornix of vaginal Interpretation: Adenocarcinoma, extrauterine (metastatic from colonic primary) Cytomorphologic Criteria: The typical columnar cells of metastatic colon carcinoma are present in this cluster of cells. These features are similar to those identified on conventional smears. However this group lacks the distinctive goblet cells. A mild degree of degeneration may be related to the preparation method. As a comparison, the lower left inset shows normal colonic mucosa. Explanatory Notes: A granular cellular debris is seen clinging to the periphery of the cellular cluster; this is compatible with tumor diathesis. Follow-up: Metastatic colon cancer