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Atlas Interpretation:
Interpreted image
Type of Preparation:
Conventional

Magnification:
Medium

Clinical History:
79 year old postmenopausal woman, being evaluated for possible Squamous cell carcinoma of vulva

Interpretation:
NILM: Atrophy

Cytomorphologic Criteria:
Sheets of uniform orderly parabasal cells are observed representing deep parabasal cells. Some nuclei show grooves, but chromatin pattern is fine. Atrophic cells may have nucleoli (lower right insert).

Explanatory Notes:
Differentiate from HSIL by uniform bland nuclei and orderly cell arrangement. Background clues may be helpful.

Bethesda Interobserver Reproducibility Data:
NILM: Negative for Intraepithelial Lesion or Malignancy # people picked NILM: Negative for Intraepithelial Lesion or Malignancy 330 68%
Endometrial cells in a woman >= 40 # people picked Endometrial cells in a woman >= 40 7 1%
ASC-US # people picked ASC-US 21 4%
ASC-H # people picked ASC-H 17 4%
LSIL # people picked LSIL 0 0%
HSIL # people picked HSIL 12 2%
Invasive Squamous Cell Carcinoma # people picked Invasive Squamous Cell Carcinoma 14 3%
Atypical Endocervical Cells # people picked Atypical Endocervical Cells 35 7%
Atypical Endometrial Cells # people picked Atypical Endometrial Cells 14 3%
Adenocarcinoma in situ (AIS), Endocervical # people picked Adenocarcinoma in situ (AIS), Endocervical 10 2%
Adenocarcinoma # people picked Adenocarcinoma 22 5%
 
482 interpretations were submitted.

See Also: thumbnail for figure DS-110.jpg
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